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MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA- c) is a small peptide comprised of 16 amino acids, which is encoded by DNA not in the nucleus, but inside the mitochondrial genome, specifically inside the gene that encodes the mitochondrial 12S ribosomal RNA

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For conditions where there are defective nerves, such as peripheral neuropathy, neuralgia, and Mortons neuroma or any interspace perineural neuritis, injecting a concentrated B12 dose directly around the nerve has been shown to promote nerve repair and diminish pain from nerve damage