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Future research should critically evaluate whether sufficient active curcumin (or its metabolites) reaches oral or systemic target tissues at pharmacologically relevant concentrations in humans, and whether observed clinical benefits correlate with biologically plausible exposureresponse relationships

Together, providing the innate harmful effect of NOS blocker L-NAME itself, these findings may emphasize the positive significance of NO in protecting retinal neurons (and thereby, harmful effect of NOS-blockers ( Furthermore, it was demonstrated that NO is continuously produced in the retina and essential for maintenance of retinal blood flow (Vukojevic et al., 2018

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