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declares having received consulting honoraria from Amgen, Boehringer Ingelheim, Merck, Pfizer, Aegerion, Novartis, Sanofi, Takeda, Novo Nordisk and Bayer, and research grants from British Heart Foundation, MRC (UK), NIHR, PHE, MSD, Pfizer, Aegerion, Colgate and Roche

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The MHRA-approved hydroxocobalamin formulation is the preferred injectable form in the UK, as it has a longer duration of action compared to cyanocobalamin

In the multivariate Cox regression analyses, crude favorable prognostic factors included a good ECOG-PS before pemetrexed exposure, BMI 20.66, FA level 5.55 ng/mL before premedication, higher serum RBP level before pemetrexed treatment, SI G) (Supplementary Table S5(a))