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Description

Nature 1978

Crosstalk between Nrf2 and ferroptosis As an important stress factor that maintains intracellular oxidative homoeostasis, Nrf2 controls the expression of many antioxidant genes

This study identifies loss of LKB1 in KRAS* lung cancer results in an increased dependency on the hexosamine biosynthesis pathway, providing a prime example for how co-occurring mutations cooperate with KRAS* to direct metabolism