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It was reported that paclitaxel-induced mechanical hypersensitivity were increased in the DRG of mice by up-regulation of PKC (Dutra et al., 2015)

Whether mitochondrial quality control can restore the function of aggregated lipoylated proteins or other copper-affected enzymes in the pathogenesis of cuproptosis, as some regulatory systems, including the UPS, may be inhibited by copper [147]

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Its strengths in high-throughput screening, real-time imaging, and rapid genetic manipulation enable the efficient prioritization of candidates and mechanistic hypothesis generation, which can then be validated in mammalian systems