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The BBB, composed of tightly joined endothelial cells, astrocytic end-feet, and pericytes, serves as a selective barrier that regulates the passage of substances from the bloodstream into the brain parenchyma (Oldendorf, 1971), while macromolecules such as transferrin and insulin use endothelial receptor-mediated transport (Nance et al., 2022)

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Very recent study found significant improvement of behavioral deficits including cognitive decline, depressive-like behaviors, in APP (NLG-F/NLG-FG-) mice due to oral GSH administration

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