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The body has mechanisms to control most of them, including ergothioneine and glutathione, but eventually enough accrue to cause damage, which has been associated with many of the diseases of aging, like cancer, coronary heart disease and Alzheimers. The amounts of ergothioneine and glutathione in mushrooms vary by species with the porcini species, a wild variety, containing the highest amount of the two compounds among the 13 species tested, the study found

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91-94 A trial in 89 women with PCOS and insulin resistance found that berberine, in combination with hormone treatment, improved lipid profiles and SHBG levels, as well as glucose metabolism and waist circumference compared with combinations of either metformin or placebo and the same hormone treatment

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