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Not all medications and nutrients are small enough to get absorbed or need breakdown via gastric enzymes for activation for the sublingual route, but whenever possible there is a benefit to using this route as it bypasses potential damage/absorption issues in the GI tract

Identification of dopaminergic neurons of the substantia nigra pars compacta as a target of manganese accumulation

Targeting ATF4-DDIT4/TXNIP induced mitochondrial dysfunction and ferroptosis: ISRIB as novel therapy for septic cardiomyopathy

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Pharmacologically, these are the regions where type-specific regulation of ACs can occur (Halls and Cooper, 2017)