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Description

while it induced more AR expression than other groups

Author contributions YP: Conceptualization, Data curation, Investigation, Methodology, Writing original draft, Validation, Visualization

To find out the structural divergence/similarity in generated models, the structures were superposed to calculate the percentage of structural overlap and RMSD values (Table 4)

Biol Trace Elem Res (2005) 104:416

Although various drugs and compounds have been listed that can target the MET channel to alleviate ototoxicity caused by cisplatin or aminoglycosides, most of these compounds, such as d-Tubocurarine, Phenoxybenzamine, and Carvedilol, not only fail to provide ear protection at high concentrations but also enhance ototoxicity, with a narrow effective dose window limiting the practical clinical application of many MET channel blockers