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Cellular Defense Peptides increase the function of native antioxidant enzymes like superoxide dismutase (SOD), catalase, and glutathione peroxidase by inducing expression or boosting enzyme stability

Since then, several clinical studies have shown its safe and effective use - but the pharmacuetical companies have decided not to (yet) pursue FDA-Approval (likely because each new FDA-Approval costs several million dollars to go through the process, and because there are a good deal of drugs used off-label in the way tranexamic acid is for melasma, especially when the drug has a long history of safety and efficacy, as is in this case)

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In normoxia (normal oxygen levels), prolyl hydroxylase hydroxylates HIF-1 at two proline residues (Pro 402 and Pro 564)