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In myeloid cells, activated nitric oxide synthase (NOS) and NO inhibit T lymphocyte function by interfering with IL-2

This pH regulation extends beyond drug sequestration, influencing autophagy, mTOR signaling, and metabolic adaptation, which are all critical determinants of therapeutic response

The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline

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