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When ADMSCs and NP cells were co-cultured in COL II hydrogel, the number of COL II-secreting NP cells was increased and the expression of the ACAN gene was up-regulated [68]

Furthermore, there is evidence that non-spherical NPs are internalized by cells at faster rates and in larger amounts than spherical NPs (Hadji and Bouchemal, 2022)

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