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Infusion of 0.5 mg/kg MMA III in rats resulted in venous thrombosis ( In vitro treatment with a trivalent mono methylated metabolite of arsenic MMA III (monomethylarsonous acid) up to 5 M for 4 h induces cell apoptosis, phosphatidylserine externalization, caspase activation, and procoagulant activity in human platelets (161)

To address this clinical need, we developed an assay to screen molecular libraries to identify novel hits that can inhibit the specific binding between Munc13-4 and STX7, two modulators of endolysosomal function necessary for eTLR activation