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PMID: 88 NumataMHiranoAYamamotoYYasudaMMiuraNSayamaKet al

Liam Andrew Swain 1 , Jenny Godley 1 , Juan G

Parallel to identification of Mn neurotoxic properties, neuroprotective strategies have been reported, and these include endogenous antioxidants (for instance, vitamin E), plant extracts (complex mixtures containing polyphenols and non-characterized components), iron chelating agents, precursors of glutathione (GSH), and synthetic compounds that can experimentally afford protection against Mn-induced neurotoxicity

PX-12 achieves a reduction in TXN1 activity either by covalently binding to the key cysteine residue Cys73 in TXN1 or by enhancing the dimerization of its oxidized form [225]

In the setting of high ROS, as is seen with G6PD-inhibition, heme production has been shown to be impaired 137