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At the same time, the extrinsic pathway is directly involved in the autoimmune attack

10.1016/j.fct.2018.02.061 37

In practice, a combination of these approaches is used

Zhang J, Xu HX, Cho WCS, Cheuk W, Li Y, Huang QH, Yang W, Xian YF, Lin ZX (2022) Brucein D augments the chemosensitivity of gemcitabine in pancreatic cancer via inhibiting the Nrf2 pathway