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Chapter 41 Primary sclerosing cholangitis Overview Primary sclerosing cholangitis (PSC) is a chronic, cholestatic liver disease of unknown etiology characterized by diffuse inflammatory destruction of intrahepatic and/or extrahepatic bile ducts that results in bile stasis, hepatic fibrosis, cirrhosis, and end-stage liver disease

A separate E/M code with modifier 25 appended is appropriate

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The main reason is that GSH-Au NCs@His does not have the capacity to form an Au-S bond, which greatly reduces the effectiveness of GSH-Au NCs@His to consume GSH, thus protecting tumor cells from ROS oxidative damage (Figure 7C)