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The simulated results of molecular docking indicated that GHK-Cu can directly bind to SIRT1 to form a protein complex, and the interacting residues in the complex are composed of GLU-230 and ASN-226 (Figure 5E)

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In addition, MMP-9 may affect the mucus layer surrounding the intestinal epithelium, where MUC2 is the most relevant component and acts as a marker of mucosal robustness