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In the CNS many of the pathological effects of kynurenine pathway activity may result from a balance between the concentrations of quinolinic acid, an agonist at glutamate receptors sensitive to N-methyl-D-aspartate (NMDA) ( In addition, over-activation of NMDA receptors is accompanied by increased microglial proliferation and activation together with cytokine production

Although deficiency of 6PGD is well documented, it appears to have little or no significance for red cell viability

323 In addition to the above two drugs, asparaginase-targeting drugs include OP-01, JZP-458, ERY-001, and PF-690

Tanning should be avoided prior to treatment because this increases the risk of complications