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J Pharmacokinet Pharmacodyn

The first two groups underwent three cycles of 5-day total sleep deprivation followed by 2-day rest, receiving daily 2 mL olive oil (CSD group) or ALA (100 mg/kg in 2 mL olive oil) (CSD + ALA group), respectively

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Given that enhanced oxidative stress, excessive apoptosis, and extensive inflammatory reaction play an essential role in the development of CSD-induced metabolic dysfunction, exogenous supplementation with anti-oxidative or anti-inflammatory agents may be worthy of trial for dietary use as an effective strategy to depress the metabolic dysfunction and improved the quality of life for those suffering from CSD

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