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Potential mechanisms in which hyperprolactinemia may induce weight gain include decreased dopaminergic tone and leptin resistance ( 5.5 Cardiovascular risk Men with PRLoma have an increased risk of cardiovascular disease (CVD), which was not found in the group of female patients with the same diagnosis ( 5.6 Bone health Increasing PRL concentrations of mild grade still stimulate bone remodeling, but with resorption predominating over bone formation ( In a study led by Mazziotti et al., fractures occurred less frequently in patients treated with CAB than in untreated patients ( 5.7 Impact on fertility Assessment of PRL levels should be remembered during the diagnosis of male infertility ( A number of studies from the past few years have suggested a major role for PRL in the context of male infertility, but in reviewing existing data involving men undergoing endocrine evaluation for abnormalities in semen parameters, hyperprolactinemia was found in widely varying percentages: from 3.6% for secondary and 8.07% for primary infertility ( On the other hand, it is also worth mentioning the Corona et al

doi: 10.3389/fimmu.2025.1657082 242