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the protein has been studied since the 1980s

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Although increasing availability of genomic sequencing and biomarker research holds promise for more targeted therapies, much important research is needed about genetic predispositions of thyroid disorders and their impact on treatment response (Donoso 2018)

Together with barrier impairment, epithelial polarization may also affect permeability since it regulates the function of proteins partition defective-3 (PARD-3) and protein phosphatase-2 (PP-1) which are involved in tight junctions formation (266)