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Additionally, significant hydrophobic interactions involving LEU162, ILE235, TYR151, HIS201, LYS200, and ALA198 contributed to the strong binding affinity

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In light of these diverse folk remedies, recent preclinical investigations and clinical trials have evaluated black seed extracts and individual phytochemicals for potential usefulness in treating cardiometabolic disorders, arthritis and pain management, and respiratory inflammation

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Some mushrooms, such as shitake, reishi, and snow, are also natural sources of kojic acid, says board-certified dermatologist David Kim, MD