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[Abstract] Western blot analysis and densitometric quantification of MT1, Cleaved Caspase-9, Bax, Bcl-2, Cleaved Caspase-3, and Cytochrome c in the testis of SF mice treated with MEL (10 mg/kg

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Akkermansia muciniphila supplementation improves PD-1 blockade efficacy in MAFLD-related HCC models by restoring intestinal barrier integrity, lowering LPS and BA metabolite translocation, and reducing suppressive cells (MDSCs, M2 macrophages), thereby enhancing CD8 + T cell infiltration ( + T cell activation ( + T cell exhaustion and impair anti-tumor immunity ( While this review emphasizes BAs, other gut microbiota-derived metabolites (e.g., inosine, short-chain fatty acids) also regulate CD8 + T cells through distinct pathways ( + T cell metabolic circuits remains under investigation ( In summary, BA metabolites from the gut microbiota critically shape CD8 + T cell-mediated anti-tumor immunity and ICI responsiveness

These sirtuins are known as the guardians of the genome due to their role in regulating cellular homeostasis

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