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However, the fraction of CA IX positive cells is still relatively large to provide a targetable terrain

Lyophilized material kept frozen may remain stable for years when handled correctly

Slit-lamp biomicroscopic evaluation was used to grade the corneal transparency according to a previously published scale 67 , uncorrected visual acuity and BCVA were determined by the Snellen eye chart and spectacles, and expressed in the logMAR scale, Scheimpflug-based anterior segment tomography was performed to assess corneal steepness (Pentacam HR, Oculus, Optikgerate GmbH), and refraction was assessed at various post-operative visits

the copolymer (C) in the first coating including the copolymer (C-1 ) and/or the copolymer (C-2), is obtained from an aqueous dispersion of the respective copolymer (i.e., copolymer (C), copolymer (C-1 ) or copolymer (C-2))

On the other hand, an increase in oxidative stress markers, including those associated with DNA damage, was observed in exposed animals, along with the induction of NF-kB dependent pro-inflammatory mediators: TNF-, IL-1, IL-6 and COX-2