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Similar content being viewed by others Introduction Melanin synthesis is a sequence of convoluted biochemical events and involves tyrosinase family proteins such as tyrosinase, tyrosinase-related protein-1 (TRP-1), and TRP-2 1,2

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Compared to controls, ALS patient lower motor neurons exhibit significantly lower levels of these epigenetic markers, suggesting an association between TDP-43 and DNA methylation, while changes in glial cell methylation are minimal and primarily affect lower motor neurons (151)

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