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Bothmann, G, Andreeff M , Rummel H

In diabetic state, hyperglycemia and AGEs can inhibit the activation of AMPK, reduce glucose uptake, induce endothelial cells to differentiate into mesenchymal cells, and destroy the normal structure of vascular endothelial cells

The quality and reproducibility of LC-MS data was ensured using a number of measures

This process is normal, however the production of free radicals is accelerated by lifestyle factors such as poor diet, toxin exposure, smoking, stress, alcohol, or over exercising for example