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A study reported that the circadian system could control up to 80% of protein-coding genes in primates by orchestrating diverse biochemical processes [6]

Discussion and conclusion By targeting the AMPK signaling pathway with natural products for the treatment of diabetes mellitus and its complications, we have found that AMPK, as a key molecule in metabolic regulation, is critical in maintaining energy homeostasis, regulating insulin sensitivity, and reducing inflammation (Figure 3)

Subsequently, the cells were treated with LAbs@Lip@Rapa, Lip@BMn/Rapa, and LAbs@Lip@BMn/Rapa for another 2 h

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