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We also used this approach to model the binding of MMV084978 into the Cn Acs1 CoA pocket and found a preferred orientation of the carbonyl (alpha to the phenyl) in close agreement with the crystal position of isoxazole 1 (Fig

Altogether it can be concluded that an observed elevation of cobalamin in blood merits a full diagnostic work up to assess the presence of disease

doi: 10.1007/s11356-017-1080-1 62 TsuiMTKWangW-XChuLM