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In 5xFAD mice, anxiety-like behaviors typically begin at 5 months old, with males showing more profound symptoms (Dong et al., 2020

Ercal N, Gurer-Orhan H, Aykin-Burns N

The endoplasmic reticulum also contains a NADPH-dependent mixed function oxidase system, the flavin-containing monooxygenases, which oxidizes amines and sulphur compounds