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doi: 10.1097/00002030-200311210-00009

Removed from 503A Category 2 on April 23, 2026

However, caution is advised for patients with renal impairment, as Hydroxocobalamin may accumulate in the body, potentially leading to toxicity

Current research extrapolations suggest 1216 week treatment cycles followed by 48 week rest periods, though this is based on precautionary principle rather than evidence of receptor desensitization or tolerance development