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Int J Food Sci Nutr (2021) 72:1425

Prostaglandin D2 enhances lipid accumulation through suppression of lipolysis via DP2 (CRTH2) receptors in adipocytes

Moreover, PHGDH upregulation confers resistance to MEK inhibitors in NRAS-mutant melanoma, whereas targeted PHGDH inhibition restores the sensitivity of resistant tumors to MAPK signaling pathway inhibitors by reducing intracellular glutathione levels and enhancing oxidative stress (89, 90)