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We found that NRF2 promotes the activity of the serine biosynthesis pathway, which is required for the in vitro and in vivo growth of lung cancer cells with high NRF2 activity (DeNicola et al., Nat Genet 2015)

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Binkhorst L., Bannink, M., de Bruijn, P., Ruit, J., Droogendijk, H., van Alphen, R.J., den Boer, D.T., Ho Lam, M., Jager, A., van Gelder, T

The most frequently reported are: Mild headache: Most common during weeks 1-2 at the ramp-up dose

Ongoing communication and coordinating receipt of needed services from practitioners, home- and community-based service providers, community-based social service providers, hospitals, and skilled nursing facilities (or other health care facilities), and document communication regarding the patient's psychosocial strengths and needs, functional deficits, goals, preferences, and desired outcomes, including cultural and linguistic factors, in the patient's medical record