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Biochem Biophys Res Commun (2018) 503(2):1098102

Owing to its vital role in metastasis, EMT has become a promising target for cancer metastatic therapy

In the function of substrate and products, k 2 denoted the thermodynamic constant representing the ratio between the concentrations of the products and the substrates at equilibrium while K S and K P denoted the Michaelis constants for the substrate and the production for the underlying reaction, respectively

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[27] It is often co-administered with an enzyme inhibitor of peripheral decarboxylation such as carbidopa or benserazide, to reduce the amount converted to dopamine in the periphery and thereby increase the amount of L-DOPA that enters the brain