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The one in the gut is actually tryptophan hydroxylase 1

Tirzepatide's dual GIP/GLP-1 activation produces stronger appetite suppression than semaglutide alone, with patients typically experiencing faster fat loss and improved metabolic markers like fasting glucose and triglycerides

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Results vary, and consistency often plays a role in noticeable changes

Furthermore, germ-free mice receiving the SCZ microbiome showed decreased glutamate but increased GABA levels in the hippocampus, displaying SCZ-relevant behaviors similar to other mouse models of SCZ involving glutamatergic hypofunction 88