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Abstract One of the side effects of hydroxychloroquine is ototoxicity

Mammalian Cells Cell culture Human embryonic kidney (HEK) cells were cultured in DMEM medium, containing 4.5 g/L glucose, 10 % FCS and 1 % penicillin/streptomycin, and cultivated at 37 C in a humidified atmosphere containing 5% CO 2

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Pharmacological contributors include thiazide diuretics (which inhibit renal urate secretion), cyclosporine (which reduces glomerular filtration), and pyrazinamide (which increases purine synthesis), all of which can precipitate secondary hyperuricemia (Zhang K

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