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Sun et al, 2006)

Deferasirox for Managing Iron Overload in People with Myelodysplastic Syndrome

62 Further, some patients have symptoms caused by hypovolaemia after phlebotomy or problems such as cardiac morbidity, hypoproteinaemia and thrombocytopenia

It involved 31102 participants, with 256 individuals combined and administered doses from 500 to 4200 mg daily

Overexpression of an AKT1 Cys77Ser mutant increased cell proliferation and DNA synthesis which could not be augmented by methylglyoxal treatment like the wild-type