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7 Conclusions and perspectives In recent years, with the increasing exploration of the intestinal microenvironment, there is growing evidence that dysbiosis of the gut microbiota and disorders of iron metabolism are closely associated with the onset and progression of IBD

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LOC344887 is a target gene of NRF2 that suppresses the expression of fibrotic genes through the modulation of downstream PI3 K-Akt signaling pathways, exerting its antifibrotic action [84]