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Representative systems include Fe-HMME@DHA@MPN

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Since moonlighting behaviour of hPrdx6 is triggered by the micro-environment (i.e., cytosolic and lysosomal), the primary difference is pH (pH 7.0 for cytosol and 4.0 for lysosome)

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Mutant SOD1 forms inclusions in the presence of oxidative stress and WT SOD1 misfolds when the redox environment is dysregulated (Oeda et al., 2001)

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