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Of particular importance are the colonic microbial metaboliteslow-molecular-weight phenolic derivatives generated via gut microbiotawhich have recently attracted attention for their potential role in modulating inflammation ( Moreover, considerable interindividual variability in EC metabolism exists, predominantly driven by differences in gut microbiota composition and host enzymatic profiles ( To bridge these critical knowledge gaps, this review systematically explores the anti-inflammatory mechanisms of EC, emphasizing the interplay between its structural properties, metabolic fate, and the bioactivities of its microbial metabolites

Jul 2024;15(7):100252

Glutamate can contribute to the synthesis of glutathione through the activity of different enzymes, such as GCL

Targeting Co-Regulatory Feedback Loop of MYC and GSPT1 By MYC/GSPT1 Dual Degradation Is Synthetic Lethal in Combination with Ven/Aza in TP53 Mutant Acute Myeloid Leukemia Stem and Progenitor Cells

However, they can also cause gastrointestinal side effects such as nausea, bloating, and stomach sensitivity, especially in the early stages of treatment and dosage changes