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Whereas peaks in steady state levels may be associated with drug adverse effects, troughs may be associated with loss of efficacy

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Malinow MR, Duell PB, Hess DL, Anderson PH, Kruger WD, Phillipson BE, Gluckman RA, Block PC, and Upson BM (1998)

Why ozone is considered for joint pain Joint pain, particularly in conditions like osteoarthritis, is characterised by inflammation, oxidative stress, and tissue degeneration