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The critical factor is the cumulative time outside the fridge

10.1007/s13361-019-02288-2 148 DonaldsonL.CaponeJ

Administration of etamicastat (10 mg/kg per day, n = 45 per group), added to the drinking water, also decreased systolic blood pressure in D 2 / mice but had no significant effect in D 2 +/+ littermates

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