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Reduction of Inflammation Chronic inflammation has been shown to be a driving force of aging and many chronic diseases

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The authors suggested that environmental factors, such as ambient temperature, may modulate hypothalamic-pituitary-thyroid axis activity, contributing to fluctuations in disease activity or laboratory values in patients with Hashimotos thyroiditis, highlighting the importance of considering the seasonal context in the diagnosis and treatment of thyroid disorders.Finally, living in overly sterile environments with limited exposure to environmental agents has been linked to a higher incidence of HT, possibly due to reduced immune system training and altered microbiota composition (Klubo-Gwiezdzinska And Wartofsky 2022)

However, the overall effect was slight, as the variation explained by the combined regression model accounted for under 5% of the total variation in respiration in the two significant parameters ( R 2 = 0.027 for routine respiration and R 2 = 0.047 for ET capacity, respectively, in PBMCs)

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