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To further assess target engagement in vitro, we used a competitive fluorescence polarization (FP) assay that reports on the displacement of pomalidomideBODIPY from purified preparations of recombinant CRBNDDB1 (ref

10.1016/j.kint.2016.01.014 53 KinugasaY.NakamuraK.KamitaniH.HiraiM.YanagiharaK.KatoM.et al (2021)

Sleep apnea, a condition where breathing stops and restarts intermittently throughout sleep, has been associated with infertility in both men and women

Note that icterus and cholestasis are not synonymous

2.9 Seahorse XF Mito Stress Test assay MEC-1 and HG-3 cells were seeded at a density of 1 10 6 cells/mL and incubated for 24 hours with DMSO and CB-839 at equitoxic concentrations based on the IC 50 values established during the MTS assay