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Hematol Oncol Clin 23(3):431446 Martin MJ et al (2012) Metformin accelerates the growth of BRAFV600E-driven melanoma by upregulating VEGF-A

Studies have shown that ID reduces the expression of primary histocompatibility complex class I (MHC-I) molecules on tumor cell surfaces, diminishing the immune system's ability to recognize tumor cells (105)