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The Phase 2 trial documented consistent heart rate increases of 79 bpm and modest systolic BP elevations across all dose groups

Furthermore, the model adjusted for pretreatment order revealed a significant condition-by-order interaction on Glx/tNAA change ( F 1,242 = 4.22, P = 0.041), with differences between placebo and naltrexone pretreatment conditions most pronounced in the Naltrexone-Placebo order group (Supplementary Fig

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145 Under oxidative stress, Cys34 thiol shifts to a sulfenic acid (HSA-SOH), which can be irreversibly oxidized to the sulfinic (HSA-SO2H) and sulfonic (HSA-SO3H) acids or, through the reactions with glutathione, can be returned to the HSA-SH reduced form

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