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Differential cytotoxicity of Mn(II) and Mn(III): special reference to mitochondrial [Fe-S] containing enzymes

Concurrently, total brain ferritin levels are decreased despite elevated ferritin deposition in the substantia nigra, where an increased ferritin heavy chain-to-light chain ratio is associated with reduced iron storage stability ( The Fenton reaction, in which ferrous ions catalyze the conversion of H 2 O 2 into highly reactive hydroxyl radicals (OH), initiates lipid peroxidation by abstracting hydrogen from polyunsaturated fatty acids, ultimately driving ferroptotic cell death (Gow et al., 1996)