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The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity

212 men with PSA progressing PCa (average age 74.5 years) managed with surveillance were given a phytochemical rich supplement uniquely containing both standardised extracts and whole purified organic ginger, cranberry, pomegranate, turmeric, broccoli and green tea

and -sitosterol (Xu et al., 2023)

GT biology Gamma glutamyl transferase (GT) is a glycosylated microsomal enzyme that catalyses the transfer of a gamma-glutamyl group to acceptor peptides and L-amino acids, particularly cysteine

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