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499 A and phosphorylated Tau (p-Tau) neurofibrillary lesions lead to the pathology of neurons that display oxidative damage, impaired Ca2+ processing, reduced DNA repair, dysfunction of lysosomal and mitophagy, all of which have a positive correlation with the age-related NAD + decline

Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M, et al

Fortunately, with proper diagnosis and treatment of the root cause, most cysts either shrink or stop causing trouble

Subsequent sections will provide a detailed analysis of how MPs/NPs exacerbate PD progression through specific pathways: promoting aberrant -synuclein aggregation, inducing neuroinflammation, disrupting gut-brain axis homeostasis, interfering with mitochondrial energy metabolism, inhibiting the excitatory amino acid transporter 2(EAAT2), and triggering ferroptosis