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When the mitochondria cannot efficiently import and burn long-chain fatty acids due to membrane damage or carnitine depletion, the body is forced to rely on less efficient, anaerobic pathways for energy production

On the other hand, the research of Fukuda and co-researchers showed that there was a significant negative correlation between blood ammonia and free carnitine concentrations in epileptic children ( P = 0.003) and this high serum level of ammonia was associated with increased severity of seizures in their series of patients 25

Patients with COPD are often complicated with protein-energy malnutrition, so the diet should be supplied with sufficient calories ( 2 after oxidation in the body, causing or aggravating CO 2 retention, aggravating dyspnoea and the burden of diaphragm, so the diet of COPD patients should reduce the energy supply ratio of carbohydrates (Schols et al., 2014)

In females, CT2 is highly expressed in the endometrium

Together, these efforts are intended to establish a streamlined, cost-effective, and scalable platform for the genetic diagnosis of CCD, with significant implications for both newborn and selective screening programs