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doi: 10.21037/tcr-2025-128 110 RoperSJCoyleB

In a recent double-blind, randomized, placebo-controlled trial in women with abnormal mammograms, two-to-eight week consumption of about 250 mg/day of broccoli seed extract (~220 mg of glucoraphanin/day) before surgery failed to affect the expression of markers of proliferation and gene expression, including ki-67, p21, HDACs, and acetylated histones, in breast tissues collected after surgery (62)

Patients in major metropolitan areas including Los Angeles, New York, Houston, and Miami, where concierge medicine, functional medicine, and sports medicine clinics frequently offer cutting-edge supplements and unapproved therapies, are most likely to be targeted with marketing for these compounds once they become more accessible through regulated channels

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Funding This work was financially supported by a grant from the Agriculture Funding Consortium (2018F019R)